Phosgene is formed during the free radical induced degradation of chlorinated hydrocarbons.
Determination of phosgene in air samples using thermal desorption (TD) followed by gas chromatography-mass spectrometry (GC-MS) has been reported.

Application
Phosgene solution (15 wt. % in toluene) has been used to synthesize the following peptide monomers:
• γ-(4-propargyloxybenzyl)-L-glutamic acid N-carboxyanhydride (POB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate N-carboxyanhydride (DMNB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-D-glutamate N-carboxyanhydride (DMNB-D-Glu-NCA)
• 2-nitrobenzyl(4-vinylphenyl)carbamate

Phosgene solution may be used in the synthesis of:
• sulfonyl chlorides
• Fmoc (Fluorenylmethyloxycarbonyl chloride)-taurylsulfonyl chloride
• O-benzyl-L-serine carboxyanhydride